ʻOlivetol, i ʻike ʻia ʻo 5-pentylresorcinol, he hui kūlohelohe i loaʻa i ka nānā nui ʻana i nā makahiki i hala iho nei no kāna mau lāʻau lapaʻau a me nā noi ʻoihana.He mole mua ia no ka biosynthesis o nā pūhui like ʻole, me nā cannabinoids i loaʻa mua i ka mea kanu cannabis.Ka hoomaopopo ana i ka biosynthesis oʻolivetolHe mea koʻikoʻi ia e ʻike i kona hiki a e ʻimi i kāna mau noi like ʻole.
ʻO ka biosynthesis oʻOlivetolhoʻomaka me ka condensation o ʻelua mau mole o malonyl-CoA, i loaʻa mai ka acetyl-CoA, ma o ka hana a kahi enzyme i kapa ʻia polyketide synthase.Ke alakaʻi nei kēia hopena condensation i ka hoʻokumu ʻana o kahi pūhui waena i kapa ʻia ʻo geranyl pyrophosphate, kahi mea maʻamau i ka biosynthesis o nā huahana kūlohelohe, me nā terpenes.
Hoʻololi ʻia ʻo Geranyl pyrophosphate i loko o ka ʻoliva ma o ke ʻano o nā hopena enzymatic.ʻO ka hana mua e pili ana i ka hoʻoili ʻana i kahi pūʻulu isoprenyl mai geranyl pyrophosphate i kahi mole hexanoyl-CoA, e hana ana i kahi pūhui i kapa ʻia hexanoyl-CoA olive acid cyclase.Hoʻopili ʻia kēia hopena cyclization e kahi enzyme i kapa ʻia hexanoyl-CoA: olivelate cyclase.
ʻO ka hana aʻe i lokoʻolivetolʻO ka biosynthesis ka hoʻololi ʻana o ka hexanoyl-CoA olivetate cyclase i loko o kahi ʻano hana i kapa ʻia he tetraketide intermediate.Loaʻa kēia ma o ke ʻano o nā hopena enzymatic i hoʻopaʻa ʻia e nā enzyme e like me ka chalcone synthase, stilbene synthase, a me resveratrol synthase.Ke alakaʻi nei kēia mau hopena i ka hoʻokumu ʻana o nā intermediates tetraketide, a laila hoʻololi ʻia i olivetol e ka hana o ka polyketide reductase.
Pākahiʻolivetolua hoʻohui ʻia, hiki ke hoʻololi hou ʻia i loko o nā pūhui like ʻole, me nā cannabinoids, ma o ka hana o nā enzymes e like me cannabidiolic acid synthase a me delta-9-tetrahydrocannabinolic acid synthase.Hoʻopili kēia mau enzymes i ka condensation oʻolivetolme geranyl pyrophosphate a i ʻole nā molekole precursor e hana i nā cannabinoids like ʻole.
Ma kahi o kāna kuleana i ka biosynthesis cannabinoid,ʻolivetolua ʻike ʻia he mau waiwai antifungal a me antioxidant.Ua hōʻike nā haʻawina i kēlāʻolivetolhiki ke pale i ka ulu ʻana o nā ʻano fungal pathogens, e lilo ia i moho hoʻohiki no ka hoʻomohala ʻana i nā lāʻau antifungal.Eia hou,ʻolivetolua hōʻike ʻia he hana scavenging ikaika e kūʻē i nā radical manuahi, ʻo ia nā molekole reactive e hiki ke hōʻeha i nā cell a me nā ʻiʻo.ʻO kēia waiwai antioxidant oʻolivetolhōʻike i kona hiki ke hoʻohana i ka hoʻomohala ʻana i nā mea lapaʻau no ka mālama ʻana i nā maʻi pili i ke koʻikoʻi oxidative.
I ka hōʻuluʻulu ʻana, ka biosynthesis oʻolivetolpili i ka condensation o malonyl-CoA mole, a ukali ʻia e kekahi ʻano o nā hopena enzymatic, ka hopena i ka hoʻokumu ʻana oʻolivetol.Hana ʻia kēia pūhui ma ke ʻano he mole precursor i ka biosynthesis o cannabinoids a me nā huahana kūlohelohe ʻē aʻe.ʻO ka hoʻomaopopo ʻana i ke ala biosynthetic oʻOlivetolHe mea koʻikoʻi ia i ka hoʻomohala ʻana i kāna mau noi i ka lāʻau lapaʻau a me nā ʻoihana ʻoihana.Ke noiʻi hou aku i ka biosynthesis oʻolivetola ʻo kāna mau mea i loaʻa ke alakaʻi i ka loaʻa ʻana o nā pūhui therapeutic hou a kōkua i ka hoʻomohala ʻana i nā lāʻau lapaʻau hou.
Ka manawa hoʻouna: Nov-13-2023