Ua hōʻike ka hoʻokolohua i kahi kiʻekiʻe o ka quaternary ammonium disinfectants e like me ka mālama ʻana i nā maʻi he nui, me nā coronaviruses: hana kēia ma ka hoʻopau ʻana i ka uhi lipid pale i hoʻopuni ʻia i nā maʻi e like me SARS-CoV-2 hilinaʻi.Hoʻolaha nui ʻia nā pūhui ammonium Quaternary e pepehi i nā maʻi a aia ma luna o 350 mau huahana ma ka EPA's List N: Disinfectants no ka hoʻohana kūʻē iā SARS-CoV-2 (Supplementary Material. The disinfectant concentrations and contact times (pili me nā maʻi he nui) no ka nui o ka disinfecting. Ua hōʻike ʻia nā kemika ma ka papa inoa EPA a hiki i ka 140 ke hoʻopau i ka maʻi maʻi i loko o nā minuke (18).
Ua alakaʻi kēia ʻike iā mākou i ka ʻimi nui ʻana i nā pūhui ammonium quaternary me ka hana e kūʻē i nā coronaviruses a me ka hiki ke ʻike ʻia o nā kemika i hoʻāʻo ʻia i loko o ke keʻena a hiki ke hoʻohana ʻia ma ke ʻano he lāʻau lapaʻau no COVID-19.ʻO kekahi o nā disinfectants i hōʻike ʻia e luku i nā maʻi (Supplementary Material) a hoʻohana nui ʻia i nā huahana mālama pilikino ʻo cetylpyridinium chloride.Loaʻa ʻia kēia pūhui i loko o nā waha holoi a ua helu ʻia e ka FDA ma Generally Regarded as Safe (GRAS) no laila ke hoʻohana ʻia nei ma ke ʻano he antimicrobial agent no ka ʻiʻo a me nā huahana moa (a hiki i ka 1%).Ua hoʻohana ʻia ʻo Cetylpyridinium chloride i nā hoʻokolohua lapaʻau he nui, e like me ka mālama ʻana i nā maʻi hanu e hōʻoia ana i kona hoʻohana ʻana ma ke ʻano he antiviral.Hoʻoikaika paha ʻo Cetylpyridinium i ka hoʻopau ʻana i ka maʻi ma o ka luku ʻana i ka capsid a me kāna hana lysosomotropic, e like me ka mea i ʻōlelo ʻia ma luna nei, he mea maʻamau no nā pūhui ammonium quaternary.Ke hāpai nei kēia i ka nīnau inā paha e hana like kekahi o nā lāʻau lapaʻau i ʻike ʻia me ka hana antiviral e kūʻē iā SARS-CoV-2 in vitro, ʻo ia hoʻi, hiki iā lākou ke luku i ka capsid virus a me ka hōʻiliʻili ʻana i ka lysosome a i ʻole endosomes a hoʻopaʻa hope i ke komo ʻana i ka viral.Ua hōʻike ʻia nā haʻawina hou i paʻi ʻia e hiki ke hoʻemi ʻia kēia hopena ma o ka hoʻohana ʻana i nā mea hoʻopaneʻe Cathepsin-L.
Cetylpyridinium chloride(CPC)
ʻO nā pūhui ammonium Quaternary me ka hana coronavirus i ʻike ʻia
| Molekula | Hana antiviral | Mechanism | Ua ʻae ʻia ʻo FDA | Hoʻohana |
| Ammonium Chloride | Murine coronavirus, hepatitis C, | Lysosomotropic | ʻAe | Hoʻohana like ʻole me ka metabolic acidosis. |
| Cetylpyridinium chloride | Influenza, hepatitis B, poliovirus 1 | Kuhi ʻia ka capsid a he lysosomotropic | ʻAe, GRAS | Antiseptic, mouthwash, cough lozenges, nā huahana mālama pilikino, nā mea hoʻomaʻemaʻe etc. |
Ka manawa hoʻouna: ʻAukake-03-2021