ʻO Cetylpyridinium chloride e like me nā lāʻau lapaʻau no COVID-19

Ua hōʻike ka hoʻokolohua i kahi kiʻekiʻe o ka quaternary ammonium disinfectants e like me ka mālama ʻana i nā maʻi he nui, me nā coronaviruses: hana kēia ma ka hoʻopau ʻana i ka uhi lipid pale i hoʻopuni ʻia i nā maʻi e like me SARS-CoV-2 hilinaʻi.Hoʻolaha nui ʻia nā pūhui ammonium Quaternary e pepehi i nā maʻi a aia ma luna o 350 mau huahana ma ka EPA's List N: Disinfectants no ka hoʻohana kūʻē iā SARS-CoV-2 (Supplementary Material. The disinfectant concentrations and contact times (pili me nā maʻi he nui) no ka nui o ka disinfecting. Ua hōʻike ʻia nā kemika ma ka papa inoa EPA a hiki i ka 140 ke hoʻopau i ka maʻi maʻi i loko o nā minuke (18).
Ua alakaʻi kēia ʻike iā mākou i ka ʻimi nui ʻana i nā pūhui ammonium quaternary me ka hana e kūʻē i nā coronaviruses a me ka hiki ke ʻike ʻia o nā kemika i hoʻāʻo ʻia i loko o ke keʻena a hiki ke hoʻohana ʻia ma ke ʻano he lāʻau lapaʻau no COVID-19.ʻO kekahi o nā disinfectants i hōʻike ʻia e luku i nā maʻi (Supplementary Material) a hoʻohana nui ʻia i nā huahana mālama pilikino ʻo cetylpyridinium chloride.Loaʻa ʻia kēia pūhui i loko o nā waha holoi a ua helu ʻia e ka FDA ma Generally Regarded as Safe (GRAS) no laila ke hoʻohana ʻia nei ma ke ʻano he antimicrobial agent no ka ʻiʻo a me nā huahana moa (a hiki i ka 1%).Ua hoʻohana ʻia ʻo Cetylpyridinium chloride i nā hoʻokolohua lapaʻau he nui, e like me ka mālama ʻana i nā maʻi hanu e hōʻoia ana i kona hoʻohana ʻana ma ke ʻano he antiviral.Hoʻoikaika paha ʻo Cetylpyridinium i ka hoʻopau ʻana i ka maʻi ma o ka luku ʻana i ka capsid a me kāna hana lysosomotropic, e like me ka mea i ʻōlelo ʻia ma luna nei, he mea maʻamau no nā pūhui ammonium quaternary.Ke hāpai nei kēia i ka nīnau inā paha e hana like kekahi o nā lāʻau lapaʻau i ʻike ʻia me ka hana antiviral e kūʻē iā SARS-CoV-2 in vitro, ʻo ia hoʻi, hiki iā lākou ke luku i ka capsid virus a me ka hōʻiliʻili ʻana i ka lysosome a i ʻole endosomes a hoʻopaʻa hope i ke komo ʻana i ka viral.Ua hōʻike ʻia nā haʻawina hou i paʻi ʻia e hiki ke hoʻemi ʻia kēia hopena ma o ka hoʻohana ʻana i nā mea hoʻopaneʻe Cathepsin-L.

 Cetylpyridinium chloride(CPC)

ʻO nā pūhui ammonium Quaternary me ka hana coronavirus i ʻike ʻia

Molekula

Hana antiviral

Mechanism

Ua ʻae ʻia ʻo FDA

Hoʻohana

Ammonium Chloride Murine coronavirus, hepatitis C, Lysosomotropic ʻAe Hoʻohana like ʻole me ka metabolic acidosis.
Cetylpyridinium chloride Influenza, hepatitis B, poliovirus 1 Kuhi ʻia ka capsid a he lysosomotropic ʻAe, GRAS Antiseptic, mouthwash, cough lozenges, nā huahana mālama pilikino, nā mea hoʻomaʻemaʻe etc.

Ka manawa hoʻouna: ʻAukake-03-2021